The Lee Laboratory explores mechanisms of cellular adaptation to stress conditions commonly found within the tumor microenvironment (hypoxia i.e. low oxygen and extracellular acidosis). These physiological stimuli alter fundamental cellular pathways by:

  • Activating alternative translation machineries that drive oxygen-dependent global remodeling of protein synthesis. (Please see the video below).
  • Inducing a new class of long noncoding RNAs that regulate protein mobility.

Ongoing projects blend basic and translational scientific research, from the identification of novel stress-induced long noncoding RNAs to the discovery of small molecular inhibitors against the hypoxic protein synthesis machinery.